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  1. A cost-effectiveness evaluation of newborn hemoglobinopathy screening from the perspective of state health care systems.

    Article - En anglais

    Copyright (c) 1996 Elsevier Science B.V. All rights reserved.

    Objective 

    To determine the most cost-effective strategy for newborn hemoglobinopathy screening from the perspective of state health care systems.

    Study design 

    Using Alaska as an example, we used decision analysis to compare a policy of no screening to universal or targeted screening with selective follow-up only of infants who are homozygous or compound heterozygous for an abnormal hemoglobin variant and to universal or targeted screening with complete follow-up, including follow-up of infants with clinically insignificant traits.

    Probabilities and costs were varied over values that might be expected for other states.

    Results 

    Among the selective follow-up options, targeted screening would be the most cost-effective strategy for Alaska at a cost of ? 206192 per death averted ; by contrast, universal screening would prevent 50% more deaths at an incremental cost of ? 2040000 per death averted.

    Universal would be more cost-effective than targeted screening for several scenarios expected to occur in other states, including a high sickle cell disease prevalence, a low screening test cost, and a high cost per screen associated with racial targeting. (...)

    Mots-clés Pascal : Dépistage, Coût, Optimisation, Anémie hématie falciforme, Hémopathie, Anémie hémolytique, Hémoglobinopathie, Maladie héréditaire, Alaska, Etats Unis, Amérique du Nord, Amérique, Nouveau né, Homme

    Mots-clés Pascal anglais : Medical screening, Costs, Optimization, Sickle cell anemia, Hemopathy, Hemolytic anemia, Hemoglobinopathy, Genetic disease, Alaska, United States, North America, America, Newborn, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0395235

    Code Inist : 002B19A01. Création : 10/04/1997.



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