Within an environmental health study, dermatologic examination of 1273 pre-school-age children (5-7 years old) was carried out in selected areas of East (n=287) and West (n=987) Germany in spring 1991.
On the basis of comparable genetic background, the influence of a different exposure to air pollutants on the manifestation of atopic diseases was investigated.
Halle an der Saale (East Germany) and Duisburg (North/South) as well as Essen (West Germany) were chosen as polluted study areas, whereas the countryside town of Borken (West Germany) served as a control region.
Outdoor pollution with particles and SO2 was significantly higher in Halle an der Saale.
Of the total study group, 12.9% suffered from atopic eczema at the time of examination.
The prevalence was highest in East Germany (17.5% ; adjusted odds ratio [OR] 1.39, confidence intervals [CI] 0.77-2.52, compared to Borken).
The reported frequencies of hay fever and asthma in the total study population were 2% and 1.3%, respectively, without significant differences between study sites.
Some 34.7% of the children showed at least one positive skin prick test reaction ; significantly (P<0.001) higher sensitization rates were obtained in western regions (Essen, Duisburg-South) than in the control region (Borken) and East Germany.
Multivariate analysis of the prevalence of atopic eczema showed associations with parental predisposition (OR 1.52, CI 1.03-2.25), sex (for boys, OR 0.63, CI 0.43-0. (...)
Mots-clés Pascal : Eczéma, Prévalence, Atopie, Epidémiologie, Allemagne, Europe, Polluant, Pollution air, Homme, Allergie, Immunopathologie, Peau pathologie
Mots-clés Pascal anglais : Eczema, Prevalence, Atopy, Epidemiology, Germany, Europe, Pollutant, Air pollution, Human, Allergy, Immunopathology, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0394286
Code Inist : 002B06C04. Création : 10/04/1997.