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  1. Color vision loss among styrene-exposed workers neurotoxicological threshold assessment.

    Article - En anglais

    Styrene represents nowadays one of the most used organic solvent.

    The current exposure limit proposed for this chemical differs significantly from country to country : the Threshold Limit Value - Time Weighted Average (TLV-TWA) proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) is 50 ppm while the German, Finnish and Swedish occupational exposure limit is 20 ppm.

    Nevertheless, effects on the nervous system were recently reported in workers exposed at TWA styrene levels below the current TL V. Neuro-optic pathways have been shown to be particularly vulnerable to organic solvent exposure.

    Analysis andmeasuremen ts of visual functions can provide important information on early neurotoxic effects.

    Previous studies support the hypothesis that styrene exposure can induce a dose-dependent color vision loss.

    The aim oft his study is to assess a threshold level below which no detectable effect occurs for color vision.

    We applied a sub-application of the change point problem in two-phase regression considering one phase as a constant line.

    In accordance with this model the maximum-likelihood technique was used as a method to examine the dose-effect relationship between external styrene exposure and chromatic discrimination.

    The present article presents a joint analysis of data from two previously published studies, one carried out in Canada and the other in Italy. (...)

    Mots-clés Pascal : Styrène, Exposition professionnelle, Médecine travail, Toxicité, Dyschromatopsie, Homme, Italie, Europe, Solvant organique, Oeil pathologie, Trouble vision

    Mots-clés Pascal anglais : Styrene, Occupational exposure, Occupational medicine, Toxicity, Dyschromatopsia, Human, Italy, Europe, Organic solvent, Eye disease, Vision disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0393847

    Code Inist : 002B03L04. Création : 10/04/1997.