Antioxidants have been implicated in processes related to atherosclerosis, aging, and selective neuronal damage, all of which may ultimately affect cognitive function.
In a sample of older persons, the authors examined the cross-sectional relation between cognitive function and dietary intake of bêta-carotene and vitamins C and E. The data were derived from 5,182 community participants aged 55-95 years in the population-based Rotterdam Study in the period 1990 to 1993.
Dietary intake was estimated from a semiquantitative food frequency questionnaire and categorized into five levels of intake.
Cognitive function was measured with the 30-point Mini-Mental State Examination (MMSE) and characterized as unimpaired (>25 points) or impaired (¾25 points).
Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (Cl) for cognitive impairment.
After adjustment for age, education, sex, smoking, total caloric intake, and intake of other antioxidants, a lower intake of bêta-carotene was associated with impaired cognitive function (<0.9 mg vs. = 2.1 mg intake, OR=1.9,95% Cl 1.2-3.1 ; p for trend<0.04).
There was no association between cognitive function and intake of vitamins C and E. These cross-sectional observations are compatible with the view that bêta-carotene-rich foods may protect against cognitive impairment in older people. (...)
Mots-clés Pascal : Trouble cognition, Vieillard, Homme, Epidémiologie, Régime alimentaire enrichi, Antioxydant, bêta-Carotène, alpha-Tocophérol, Ascorbique acide, Vitamine, Prévention, Pays Bas, Europe
Mots-clés Pascal anglais : Cognitive disorder, Elderly, Human, Epidemiology, Supplemented diet, Antioxidant, alpha-Tocopherol, Ascorbic acid, Vitamin, Prevention, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0393663
Code Inist : 002B18E. Création : 10/04/1997.