Background Venezuelan equine encephalomyelitis (VEE) virus has caused periodic epidemics among human beings and equines in Latin America from the 1920s to the early 1970s.
The first major outbreak since 1973 occurred in Venezuela and Colombia during 1995, and involved an estimated 75 000 to 100 000 people.
We report an epidemiological and virological investigation of this epidemic.
Methods Virus isolates were made in cell culture from human serum, human throat swabs, and brain tissue from aborted and stillborn human fetuses, as well as from horse brain tissue and pooled mosquito collections.
Human sera were also tested for VEE-specific antibodies.
The serotypes of VEE isolates were identified by antigen assays, and viruses were characterised genetically by sequencing PCR products generated from the E3 and E2 genes.
Phylogenetic analyses were done to determine evolutionary relations with respect to previous epidemic/epizootic and enzootic VEE virus isolates.
Mosquito collections were made to identify possible vectors, and clinical findings were determined by direct observation of patients visiting hospitals and clinics in affected regions, and by inspecting patient records.
Equine vaccination and vector control were used in an attempt to halt the spread of the outbreak.
Findings Most affected people had an acute, self-limited febrile illness of 3 to 4 days duration. (...)
Mots-clés Pascal : Encéphalite équine Venezuela, Arbovirose, Virose, Infection, Exploration virologique, Epidémie, Amérique du Sud, Amérique, Epidémiologie, Homme, Animal, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Venezuelan equine encephalomyelitis, Arbovirus disease, Viral disease, Infection, Virological exploration, Epidemic, South America, America, Epidemiology, Human, Animal, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0393580
Code Inist : 002B05C02I1D. Création : 10/04/1997.