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  1. Fulltext. Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults : The CARDIA Study.

    Article - En anglais


    To characterize 7-year changes in fasting serum insulin and glucose concentrations, the authors analyzed population-based data on 3,095 nondiabetic black and white men and women who were initially aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    Measurements were made of fasting insulin (by an assay with little cross-reactivity to proinsulin) and fasting glucose on frozen samples from baseline and Year 7 examinations.

    Over the 7-year period, mean fasting insulin increased 10-25%, mean fasting glucose increased 7-10%, and mean body mass increased 7-12% across the four race-sex-groups.

    The strongest predictor of both insulin increase and glucose increase was an increase in body mass over the 7 years.

    Adjusted for age and examination time period in race-sex-specific repeated measures analyses, fasting insulin increased longitudinally by approximately 5 muU/mL per 5 kg/m2 increase in body mass index (p<0.05).

    Adjusted for age and time period, fasting insulin increased over the 7 years by approximately 2.5 muU/mL per 0.08 unit increase in waist/hip ratio (p<0.05), although this association was much stronger cross-sectionally.

    In a similar model, each 100 unit decrease in physical activity longitudinally predicted a 0.1-0.2 muU/mL increase in fasting insulin (p<0.05 in black men only) ; this association was stronger and statistically significant in all race-sex-groups cross-sectionally. (...)

    Mots-clés Pascal : Poids corporel, Epidémiologie, Insuline, Hormone protéine, Glucose, Taux, Adulte jeune, Homme, Exercice physique, Tendance, Race, Sexe, Biométrie corporelle, Etats Unis, Amérique du Nord, Amérique, Etude longitudinale

    Mots-clés Pascal anglais : Body weight, Epidemiology, Insulin, Protein hormone, Glucose, Rate, Young adult, Human, Physical exercise, Trend, Race, Sex, Corporal biometry, United States, North America, America, Follow up study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0389286

    Code Inist : 002B29A. Création : 10/04/1997.