To characterize 7-year changes in fasting serum insulin and glucose concentrations, the authors analyzed population-based data on 3,095 nondiabetic black and white men and women who were initially aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Measurements were made of fasting insulin (by an assay with little cross-reactivity to proinsulin) and fasting glucose on frozen samples from baseline and Year 7 examinations.
Over the 7-year period, mean fasting insulin increased 10-25%, mean fasting glucose increased 7-10%, and mean body mass increased 7-12% across the four race-sex-groups.
The strongest predictor of both insulin increase and glucose increase was an increase in body mass over the 7 years.
Adjusted for age and examination time period in race-sex-specific repeated measures analyses, fasting insulin increased longitudinally by approximately 5 muU/mL per 5 kg/m2 increase in body mass index (p<0.05).
Adjusted for age and time period, fasting insulin increased over the 7 years by approximately 2.5 muU/mL per 0.08 unit increase in waist/hip ratio (p<0.05), although this association was much stronger cross-sectionally.
In a similar model, each 100 unit decrease in physical activity longitudinally predicted a 0.1-0.2 muU/mL increase in fasting insulin (p<0.05 in black men only) ; this association was stronger and statistically significant in all race-sex-groups cross-sectionally. (...)
Mots-clés Pascal : Poids corporel, Epidémiologie, Insuline, Hormone protéine, Glucose, Taux, Adulte jeune, Homme, Exercice physique, Tendance, Race, Sexe, Biométrie corporelle, Etats Unis, Amérique du Nord, Amérique, Etude longitudinale
Mots-clés Pascal anglais : Body weight, Epidemiology, Insulin, Protein hormone, Glucose, Rate, Young adult, Human, Physical exercise, Trend, Race, Sex, Corporal biometry, United States, North America, America, Follow up study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0389286
Code Inist : 002B29A. Création : 10/04/1997.