International Programme on Chemical Safety (IPCS) Workshop. Oslo NOR, 1995/11/29.
Diverse environmental exposure profiles exist in the Americas because of widely different climates, ambient pollutants, and bioaerosols in these continents.
This paper reviews selected studies from the Americas that support the broad hypothesis that environmental factors contribute to respiratory hypersensitivity.
Processes influenced by environmental factors include primary immunologic sensitization, the development and exacerbation of specific immunologic diseases and the activation of nonspecific mechanisms with tissue inflammation, injury and remodeling.
Endpoints resulting from these processes include respiratory symptoms, diseases such as asthma, with measures of disease severity including medication use and hospitalization rates, and death due to cardiorespiratory disease.
Studies associate sensitization rates to specific allergens with environmental factors such as humidity and indices of allergen exposure.
Regional variation occurs with exposure to outdoor source pollutants such as ozone, but varies by household to bioaerosols such as dust mite, cat or cockroach allergen.
Indoor allergens are associated with asthma while outdoor allergens are associated with allergic rhinitis.
In a national survey, the atopic sensitization rate in the USA increased with urban residence (defined as towns of population>2500) and varied by region.
Controlled human challenge studies show that ozone increases the response of allergic subjects to allergen. (...)
Mots-clés Pascal : Hypersensibilité, Homme, Epidémiologie, Asthme, Allergie, Etats Unis, Amérique du Nord, Amérique, Variation géographique, Pollution, Irritation, Gaz toxique, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie
Mots-clés Pascal anglais : Hypersensitivity, Human, Epidemiology, Asthma, Allergy, United States, North America, America, Geographical variation, Pollution, Irritation, Toxic gas, Respiratory disease, Obstructive pulmonary disease, Immunopathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0389272
Code Inist : 002B11B. Création : 10/04/1997.