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  1. Beware of surrogate outcome measures : The quality of the medical evidence : Is it good enough ?

    Article - En anglais

    Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest.

    We review the justification for their use and conclude that reliance on them may be harmful.

    Results obtained with surrogates should therefore be regarded as preliminary.

    Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.

    Mots-clés Pascal : Prise décision, Traitement, Indicateur, Pronostic, Prédiction, Homme, Evaluation, Chimiothérapie, Facteur prédictif

    Mots-clés Pascal anglais : Decision making, Treatment, Indicator, Prognosis, Prediction, Human, Evaluation, Chemotherapy, Predictive factor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0386566

    Code Inist : 002B30A11. Création : 10/04/1997.