Risk Assessment Issues for Sensitive Human Populations. Conference. Wright-Patterson AFB, OH USA, 1995/04/25.
Whether people become ill after encountering environmental pollutants depends on the magnitude of their exposure and their capacity to respond.
Exposure and intrinsic response capabilities vary within the population.
Those that become ill when the general population remains largely unaffected are considered to be highly susceptible.
The U.S. Environmental Protection Agency (USEPA), responsible for protecting the public from environmental pollutants, has developed risk assessment procedures to assist in evaluating the likelihood of health effects.
However, the Agency's ability to evaluate the risk faced by highly susceptible populations is often hindered by the paucity of adequate health effects data.
Response variability can be assessed with animal models and human epidemiological studies.
Although animal models are useful when evaluating the effect of gender and developmental stage on susceptibility, inbred rodent strains underestimate the genetic and lifestyle-induced variability in susceptibility found in human populations.
Epidemiological approaches are the preferred source of information on variability.
This paper reviews the epidemiological literature from the perspective of a risk assessor seeking data suitable for estimating the risk to highly susceptible populations.
Epidemiological approaches do not measure the full range of population response variability. (...)
Mots-clés Pascal : Epidémiologie, Polluant, Environnement, Toxicité, Homme, Relation dose réponse, Facteur risque, Comparaison interindividuelle, Prédisposition, Sensibilité, Etats Unis, Amérique du Nord, Amérique, Evaluation
Mots-clés Pascal anglais : Epidemiology, Pollutant, Environment, Toxicity, Human, Dose activity relation, Risk factor, Interindividual comparison, Predisposition, Sensitivity, United States, North America, America, Evaluation
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0381174
Code Inist : 002B03M01. Création : 10/04/1997.