Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis.
The assessment of radiographs for vertebral fractures is important in the clinical evaluation of patients with suspected osteoporosis, in the epidemiological evaluation of elderly populations, and in clinical trials of osteotrophic drugs.
The purpose of this study is to compare visual semiquantitative (SQ) approaches and quantitative morphometric approaches for assessing prevalent and incident vertebral fractures in postmenopausal osteoporosis.
We analyzed lateral thoracolumbar spine radiographs (baseline and ~3.5 year follow-up) of 503 women (age =65) randomly selected from the Study of Osteoporotic Fractures (SOF) population.
SQ assessment by an experienced radiologist graded vertebral fractures from 0 (normal) to 3 (severe).
Incident fractures by SQ were defined as an increase of<1 grade on follow-up radiographs.
Trained research assistants visually triaged women as normal, uncertain, or probably fractured and visually flagged vertebrae with moderate/severe (grade =2) prevalent fractures or with any (grade =1 change) incident fracture.
The radiographs were also digitized by research assistants, and quantitative morphometry (QM) was used to classify vertebral deformities at several cut-offs based on standard deviation (SD) reductions in height ratios from normal means, e.g., QM = 3 SD.
Incident fractures by QM were defined as a decrease in height of more than 15% (QM15) on follow-up radiographs. (...)
Mots-clés Pascal : Morphométrie, Analyse quantitative, Radiographie, Incidence, Prévalence, Interprétation, Méthodologie, Ostéoporose, Fracture pathologique, Corps vertébral, Estimation paramètre, Epidémiologie, Exploration radiologique, Système ostéoarticulaire pathologie, Ostéopathie, Homme, Femelle
Mots-clés Pascal anglais : Morphometry, Quantitative analysis, Radiography, Incidence, Prevalence, Interpretation, Methodology, Osteoporosis, Pathologic fracture, Vertebral body, Parameter estimation, Epidemiology, Radiologic investigation, Diseases of the osteoarticular system, Bone disease, Human, Female
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0378090
Code Inist : 002B15A. Création : 10/04/1997.