Although hepatitis C virus (HCV) infection is recognized as an important risk factor for hepatocellular carcinoma (HCC), the strength of this association has been inconsistent.
In addition, the role of specific HCV genotypes in HCC progression has not yet been determined.
We conducted a case-control study to estimate the relative risk (RR) of HCC in relation to HCV infection among residents of the Fukuoka Prefecture, where HCC risk is among the highest in Japan, and to examine whether the risk differs according to HCV genotypes and/or HCV RNA titers.
Stored serum samples obtained from 91 patients with HCC and 410 healthy control subjects, who had been frequency matched to the patients with regard to sex and age, were tested for antibodies to HCV by use of second-generation immunoradiometric and immunoblot assays.
The presence of serum HCV RNA and of specific HCV genotypes was determined by use of polymerase chain reaction-based assays, and HCV RNA titers were measured by use of a branched DNA assay.
Antibodies to HCV were detected in 71 patients (78.0%) and in 30 control subjects (7.3%), of whom 57 patients and 25 control subjects had serum HCV RNA.
One patient was positive for HCV RNA but not for antibodies to HCV.
The sex-and age-adjusted RR of HCC among individuals positive for antibodies to HCV was estimated to be 53.7 (95% confidence interval [Cl]=27.1-106.2). (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Homme, Mongoloïde, Hépatite virale C, Virose, Infection, Analyse risque, Epidémiologie, RNA, Sérum, Concentration, Génotype, Japon, Asie, Virus hépatite C, Flaviviridae, Virus, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Liver cell carcinoma, Human, Mongoloid, Viral hepatitis C, Viral disease, Infection, Risk analysis, Epidemiology, RNA, Serum, Concentration, Genotype, Japan, Asia, Hepatitis C virus, Flaviviridae, Virus, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0376734
Code Inist : 002B13C01. Création : 10/04/1997.