Objectives-Organophosphates are effective pesticides which are frequently used in several agricultural settings.
Although their acute effects are well characterised, it remains unclear whether long term exposure can damage the human nervous system.
This study sought to investigate their long term effects by comparing abnormalities on neurological examination between groups of workers exposed to organophosphates and an unexposed group.
Methods-146 exposed sheep farmers and 143 unexposed quarry workers were recruited into a cross sectional study of symptoms and neuropsychological effects of long term exposure to organophosphates in sheep dip.
From a symptom questionnaire given immediately after dipping the 10 most symptomatic and 10 least symptomatic farmers were selected.
Several months later each of these, along with 10 of the unexposed quarry workers, underwent a standardised neurological examination similar to that which might be used in clinical practice, at a time as remote as possible from recent exposure to organophosphates so as to exclude any acute effects.
All 30 selected subjects agreed to participate. (...)
Mots-clés Pascal : Pesticide, Organophosphoré, Agriculteur, Toxicité, Homme, Exposition professionnelle, Médecine travail, Epidémiologie, Grande Bretagne, Royaume Uni, Europe, Malformation, Symptomatologie, Questionnaire, Système nerveux pathologie
Mots-clés Pascal anglais : Pesticides, Organophosphorus compounds, Farmer, Toxicity, Human, Occupational exposure, Occupational medicine, Epidemiology, Great Britain, United Kingdom, Europe, Malformation, Symptomatology, Questionnaire, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0376239
Code Inist : 002B03G. Création : 10/04/1997.