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  1. Detection of human papillomavirus in esophageal squamous cell carcinoma.

    Article - En anglais


    Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas.

    However, the incidence of HPV varies significantly in different geographic locations.

    In the current study, neoplasms from two separate geographic regions were analyzed for the presence of HPV DNA.


    One hundred and ten esophageal squamous cell carcinomas, 83 from Beijing, China and 27 from Cincinnati, Ohio, were examined for the presence of HPV DNA.

    In situ hybridization and polymerase chain reaction (PCR) using both consensus primers for the HPV L1 gene and type specific primers for the E6 gene of HPV types 6,16, and 18 were performed.


    In situ hybridization failed to demonstrate any HPV type (6,11,16,18,31,33, or 35) in any tumor specimen.

    Likewise, PCR using consensus primers for the HPV L1 gene was negative in all samples.

    Three of the Chinese specimens (4.29%) were positive for HPV using E6 type specific primers.

    One tumor contained HPV type 6 DNA, whereas the other 2 contained HPV type 16 DNA.

    One Cincinnati tumor (4.35%) was positive for HPV 16 by type specific primer.

    None of the specimens contained HPV 18 DNA.


    The incidence of HPV DNA in esophageal carcinoma specimens from Beijing, China and Cincinnati, Ohio is similar.

    The incidence of HPV in tumors from Beijing is significantly lower than that reported for those from other regions of China where the incidence of esophageal cancer is higher. (...)

    Mots-clés Pascal : Carcinome épidermoïde, Oesophage, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Incidence, Epidémiologie, Ohio, Etats Unis, Amérique du Nord, Amérique, Chine, Asie, Homme, Tumeur maligne, Appareil digestif pathologie, Oesophage pathologie

    Mots-clés Pascal anglais : Squamous cell carcinoma, Esophagus, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Incidence, Epidemiology, Ohio, United States, North America, America, China, Asia, Human, Malignant tumor, Digestive diseases, Esophageal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0375198

    Code Inist : 002B13A01. Création : 10/04/1997.