The association between dietary antioxidant vitamin intake and the risk of breast cancer was examined in a prospective study of 34,387 postmenopausal women in Iowa.
Intakes of vitamins A, C, and E and of retinol and carotenoids were assessed in 1986 by mailed semiquantitative food frequency questionnaire.
Through December 31,1992,879 incident breast cancer cases occurred in this cohort.
There was little suggestion that breast cancer risk was associated with differences in intake of these vitamins.
For example, from the lowest to highest total vitamin A intake categorized by quintiles, the age-adjusted relative risks of breast cancer were 1.0,0.95,1.17,1.20, and 0.90 (p trend=0.92).
Similarly unremarkable relative risk patterns were seen for the intakes of vitamins C and E and of retinol and carotenoids.
These findings were not altered after adjustment for breast cancer risk factors or in analyses confined to women who reported no supplemental vitamin intake.
Exclusion of cases that occurred in the first 2 years of follow-up, under the assumption that women may have increased intake of these vitamins in response to preclinical symptoms of breast cancer, did not suggest an inverse association of these vitamins with the risk of breast cancer.
Women who reported consuming at least 500 mg/day of supplemental vitamin C had a relative risk of breast cancer of 0. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Postménopause, Epidémiologie, Femme, Homme, Antioxydant, Rétinol, Ascorbique acide, alpha-Tocophérol, Vitamine, Carotène, Régime alimentaire enrichi, Iowa, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Postmenopause, Epidemiology, Woman, Human, Antioxidant, Retinol, Ascorbic acid, alpha-Tocopherol, Vitamin, Carotene, Supplemented diet, Iowa, United States, North America, America, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0375071
Code Inist : 002B20E02. Création : 10/04/1997.