A population-based study of cancer risk in twins : Relationships to birth order and sexes of the twin pair.
One thousand and sixty-three twins with cancer whose co-twin was born alive were identified among patients born since September 1939 with cancers incident in England and Wales during 1971-1984 at childhood and young adult ages.
Site-specific risks of cancer were analysed in relation to birth order within the twinship and sexes of the twin pair, using adjusted national birth data to give control distributions of these variables.
Risk of leukaemia was increased in first-born twins, risk of testicular cancer was increased in second-born twins with female co-twins but decreased in second-born twins with male co-twins and lung cancer risk was increased in first-born twins with same-sex co-twins.
Cutaneous melanoma risk was increased in persons with opposite-sex co-twins, nervous system cancer risk was increased in females with opposite-sex co-twins and Hodgkin's disease risk was increased in persons with same-sex co-twins.
For most of the findings, no previous comparable analyses are available, so interpretation of the results must be provisional until the analyses can be repeated on other data.
The result for leukaemia would accord with previous suggestions that leukaemia may be of prenatal origin and may sometimes lead to intrauterine death. (...)
Mots-clés Pascal : Tumeur maligne, Epidémiologie, Facteur risque, Lymphome, Leucémie, Rang naissance, Sexe, Jumeau, Angleterre, Grande Bretagne, Royaume Uni, Europe, Pays de Galles, Enfant, Homme, Adulte jeune, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Malignant tumor, Epidemiology, Risk factor, Lymphoma, Leukemia, Birth order, Sex, Twin, England, Great Britain, United Kingdom, Europe, Wales, Child, Human, Young adult, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0371289
Code Inist : 002B04B. Création : 10/04/1997.