JP-8 aviation fuel is being phased in as a replacement for both JP-4 and JP-5 jet fuels presently in use by the Air Force and Navy, respectively.
At the present time, 11% of active-duty Air Force personnel are women of child-bearing age.
This study was undertaken to determine the threat posed to the unborn fetus should female active-duty personnel come in contact with JP-8 while pregnant.
Time-mated Sprague-Dawley rats were dosed orally with JP-8 at 0,500,1000,1500 and 2000 mg kg-1 day-1 on days 6-15 of pregnancy.
The number and type of fetal malformations and variations observed did not differ significantly between dose groups.
Dams in the 1000,1500 and 2000 mg kg-1 day-1 groups gained significantly less body weight during pregnancy than did control dams.
Embryo toxicity was indicated by a significant reduction in fetal body weight in the 1500 and 2000 mg kg-1 day-1 dose groups.
Mots-clés Pascal : Carburéacteur, Carburant, Avion, Toxicité, Tératogène, Foetus, Homme, Exposition professionnelle, Médecine travail, Rat, Rodentia, Mammalia, Vertebrata, Animal, Voie orale, Malformation, Fuel JP8
Mots-clés Pascal anglais : Jet fuel, Motor fuel, Airplane, Toxicity, Teratogen, Fetus, Human, Occupational exposure, Occupational medicine, Rat, Rodentia, Mammalia, Vertebrata, Animal, Oral administration, Malformation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0370653
Code Inist : 002A30E. Création : 10/04/1997.