N-methyl-2-pyrrolidone is a solvent that is increasingly used in a variety of industries, including petroleum refining, microelectronics, pesticide formulation, and veterinary medicine.
Animal studies have demonstrated fetotoxic effects after maternal exposure to doses that have minimal to no adverse effect on the mothers.
The fetotoxicity comprises resorption, stillbirth, and low birthweight and delayed ossification in surviving young.
We report a human case of intrauterine growth retardation followed by fetal demise at 31 weeks gestation.
The mother was a laboratory worker with no other apparent risk factors, who sustained occupational exposure to N-methyl-2pyrrolidone throughout the first trimester of pregnancy.
Laboratory work and solvent exposure have both previously been associated with adverse reproductive outcomes.
Laboratories and other industries that use suspected reproductive toxins should have reproductive health policies in place that allow for decision-making based on toxicologic review, exposure assessment, and medical evaluation.
These policies should allow for voluntary removal of prospective parents until environmental assessment and controls are instituted.
Mots-clés Pascal : Composé chimique, Toxicité, Solvant organique, Foetus, Exposition professionnelle, Médecine travail, Femme, Homme, Etude cas, Tératogène, Gestation, Pyrrolidin-2-one(1-méthyl)
Mots-clés Pascal anglais : Chemical compound, Toxicity, Organic solvent, Fetus, Occupational exposure, Occupational medicine, Woman, Human, Case study, Teratogen, Pregnancy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0367957
Code Inist : 002A30E. Création : 10/04/1997.