Lymphocyte bêta2-adrenoceptor receptors and plasma catecholamine levels in lead-exposed workers.
The effect of lead exposure on bêta2-adrenoceptor density and catecholamine response was studied in 26 male workers and 1 female worker, exposed to lead on average for 6 years.
The systolic blood pressure in lead workers (101-160 mmHg, 124.4 ± 14.7 mmHg) was found to be significantly higher than in controls (97-134 mmHg, 115.4 ± 10.4 mmHg, p<0.01) as was plasma norepinephrine (0.51 ± 0.1 mug/liter vs 0.24 ± 0.05 mug/liter, p<0.01).
The density of lymphocyte bêta2-adrenergic receptors (Bmax) in lead-exposed workers was 86% lower than that in controls (0.15 ± 0.08 vs 1.08 ± 0.29 fmol/0.1 X 106 cells ; p<0.01).
The dissociation constants (Kd) of [125I]iodocyanopindolol were 93.6 ± 42.6 and 87.9 ± 42.7 pM in lead-exposed workers and controls, respectively.
Multiple linear regression analysis showed that elevation of systolic pressure was closely related to (a) blood lead levels, (b) decreased bêta2-adrenergic receptor density, and (c) increased plasma catecholamine levels in lead-exposed workers.
Linear regression analysis revealed that both plasma norepinephrine levels and bêta2-adrenoceptor density (Bmax) were highly correlated with both systolic blood pressures and blood lead levels in lead-exposed workers, and a highly significant negative correlation was found to exist between Bmax and plasma norepinephrine levels (r=-0.82, p<0.001). (...)
Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Lymphocyte, Récepteur bêta2-adrénergique, Catécholamine, Pression sanguine, Epidémiologie
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Lymphocyte, bêta2-Adrenergic receptor, Catecholamine, Blood pressure, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0367788
Code Inist : 002B03L05. Création : 10/04/1997.