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  1. Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study.

    Article - En anglais


    - To determine if the long-term incidence of the acquired immunodeficiency syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels measured early in HIV-1 infection.


    - Epidemiologic cohort study.


    - Five hemophilia treatment centers in the United States.


    - A total of 165 subjects with hemophilia and HIV-1 infection (age at HIV-1 seroconversion, 1-66 years) followed from 1979 to 1995.


    - The HIV-1 RNA level was measured by polymerase chain reaction over a range of 200 to 1 million or more HIV-1 RNA copies/mL in archived serum specimens collected 12 to 36 months (median, 27 months) after the estimated date of HIV-1 seroconversion.

    Kaplan-Meier methods were used to examine the risk of AIDS and proportional hazards models were used to estimate relative hazards.


    - The HIV-1 RNA values were similar in subjects youngerthan 17 years at seroconversion (median, 5214 copies/mL) and those 18 to 34 years old (median, 4693 copies/mL), but higher in those 35 years or older (median, 12069 copies/mL) (P=02 compared with each younger group). (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Hémophilie, Incidence, Long terme, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Etude multicentrique, Epidémiologie, Homme, Etude cohorte, Prospective, Immunopathologie, Immunodéficit, Hémopathie, Coagulopathie, Maladie héréditaire

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Hemophilia, Incidence, Long term, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Multicenter study, Epidemiology, Human, Cohort study, Prospective, Immunopathology, Immune deficiency, Hemopathy, Coagulopathy, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0352352

    Code Inist : 002B30A01A1. Création : 10/04/1997.