Familial predisposition for degenerative disc disease : A case control study.
This case-control study was undertaken to determine if relatives of patients who had been admitted for surgery for degenerative disc disease-related problems were at increased risk for lower back pain or sciatica.
To determine if familial factors play a role in placing a person at risk for development of degenerative disc disease of the lumbar spine.
Summary of Background Data
It is known that smoking and various occupational factors can place a person at risk for degenerative disc disease problems.
It is not known if a familial predisposition may also exist.
The family members and relatives of 65 patients who had undergone surgery for lumbar degenerative disc disease were interviewed with a standardized questionnaire and compared with a control group of 67 patients who had been admitted to hospital for non-spine-related orthopedic procedures.
The same interview and standardized questionnaire was used for both groups by a single observer.
In the study group of 65 patients who had undergone surgery for degenerative disc disease, 44.6% were noted to have a positive family history, whereas 25.4% of the patients in the control group had a positive family history.
Eighteen and one-half percent of relatives in the study group had a history of having spinal surgery, compared with only 4.5% of the control group.
Mots-clés Pascal : Arthrose, Rachis lombaire, Disque intervertébral, Adulte, Homme, Facteur risque, Etude familiale, Déterminisme génétique, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Rachis pathologie
Mots-clés Pascal anglais : Osteoarthritis, Lumbar spine, Intervertebral disk, Adult, Human, Risk factor, Family study, Genetic inheritance, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Spine disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0351867
Code Inist : 002B15E. Création : 10/04/1997.