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  1. Familial predisposition for degenerative disc disease : A case control study.

    Article - En anglais

    Study Design

    This case-control study was undertaken to determine if relatives of patients who had been admitted for surgery for degenerative disc disease-related problems were at increased risk for lower back pain or sciatica.


    To determine if familial factors play a role in placing a person at risk for development of degenerative disc disease of the lumbar spine.

    Summary of Background Data

    It is known that smoking and various occupational factors can place a person at risk for degenerative disc disease problems.

    It is not known if a familial predisposition may also exist.


    The family members and relatives of 65 patients who had undergone surgery for lumbar degenerative disc disease were interviewed with a standardized questionnaire and compared with a control group of 67 patients who had been admitted to hospital for non-spine-related orthopedic procedures.

    The same interview and standardized questionnaire was used for both groups by a single observer.


    In the study group of 65 patients who had undergone surgery for degenerative disc disease, 44.6% were noted to have a positive family history, whereas 25.4% of the patients in the control group had a positive family history.

    Eighteen and one-half percent of relatives in the study group had a history of having spinal surgery, compared with only 4.5% of the control group.



    Mots-clés Pascal : Arthrose, Rachis lombaire, Disque intervertébral, Adulte, Homme, Facteur risque, Etude familiale, Déterminisme génétique, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Rachis pathologie

    Mots-clés Pascal anglais : Osteoarthritis, Lumbar spine, Intervertebral disk, Adult, Human, Risk factor, Family study, Genetic inheritance, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Spine disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0351867

    Code Inist : 002B15E. Création : 10/04/1997.