The plasticizer di (2-ethylhexyl) phthalate (DEHP), to which humans are extensively exposed, was found to be hepatocarcinogenic in rats and mice.
DEHP is potentially set free from objects made of synthetic materials (e.g., those used in medicine).
Chronically, the greatest amounts are transferred to persons undergoing hemodialysis (up to 3.1 mg/kg b.w. per day) who would thus be considered the individuals most endangered by tumorigenesis.
Although toxicokinetics seem to play a certain unclear role in the course of DEHP-related toxicity, toxicodynamic factors appear more decisive.
DEHP is a representative of « peroxisome proliferators » (PP), a distinct group of substances that, in rodents, do not only induce peroxisomes but also specific enzymes in other organelles, organ growth, and DNA synthesis.
The cluster of the characteristic effects of PP is generally, although perhaps not quite appropriately summarized as « peroxisome proliferation, » and is strongest in the liver.
The lowest observed effect level (LOEL) and the no observed effect level (NOEL) of peroxisome proliferation in the rat, as determined by the induction of specific enzymes (peroxisomal bêta-oxidation, carnitine-acetyl-transferase, cytochrome P-452), DNA synthesis, and hepatomegaly, may be assumed as 50 and 25 mg/kg b.w. per day, respectively. (...)
Mots-clés Pascal : Phtalique acide ester bis[2-éthylhexyle], In vitro, Plastifiant, Toxicité, Foie pathologie, Tumeur maligne, Carcinogène, Article synthèse, Rat, Rodentia, Mammalia, Vertebrata, Souris, Animal, Extrapolation animal homme, Proliférateur peroxysome, Facteur risque, Hémodialyse, Médecine travail, Métabolisme, In vivo, Dose sans effet, Application médicale, Exposition professionnelle
Mots-clés Pascal anglais : In vitro, Plasticizer, Toxicity, Hepatic disease, Malignant tumor, Carcinogen, Review, Rat, Rodentia, Mammalia, Vertebrata, Mouse, Animal, Man animal extrapolation, Peroxisome proliferator, Risk factor, Hemodialysis, Occupational medicine, Metabolism, In vivo, No observed effect level, Medical application, Occupational exposure
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0350305
Code Inist : 002B03L06. Création : 10/04/1997.