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  1. Primary sclerosing cholangitis : clinica presentation, natural history and prognostic variables : an Italian multicentre study.

    Article - En anglais

    Objective 

    Because large-scale reports of PSC in the Mediterranean area are still lacking, in this study we evaluated by Kaplan-Meyer analysis the natural history of primary sclerosing cholangitis (PSC) in Italy and by means of other statistical methods we identified the variables most useful in predicting survival of such patients.

    Design 

    Retrospective multicentre study of unselected patients with PSC.

    Several variables involving sex, age, associated diseases, clinical features, laboratory, cholangiographic and histological findings at presentation and clinical outcome at data recording were collected by means of a detailed questionnaire.

    Setting 

    16 Italian university and regional hospitals all over the country, thus giving a geographically representative population.

    Patients 

    A total of 117 PSC patients (73 men and 44 women) ; median age 35 years.

    Methods 

    Survival analysis was performed by the Kaplan-Meyer method ; the prognostic influence on survival of collected data was evaluated by univariate khi2 analysis with Wilcoxon and log-rank tests.

    The same prognostic variables were also evaluated by multivariate analysis (Cox model), using a stepwise regression procedure.

    All statistical analyses were performed using the SAS statistical software.

    Results 

    At presentation 70% of patients were symptomatic ; symptoms did not relate to liver histology.

    Both intra-and extrahepatic bile duct lesions were detected in 46% of patients at cholangiography. (...)

    Mots-clés Pascal : Angiocholite sténosante, Primitif, Symptomatologie, Evolution, Pronostic, Surveillance, Epidémiologie, Etude statistique, Homme, Italie, Europe, Appareil digestif pathologie, Voie biliaire pathologie

    Mots-clés Pascal anglais : Sclerosing cholangitis, Primitive, Symptomatology, Evolution, Prognosis, Surveillance, Epidemiology, Statistical study, Human, Italy, Europe, Digestive diseases, Biliary tract disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0346638

    Code Inist : 002B13C03. Création : 10/04/1997.