In a cohort study of human T-lymphotropic virus type I (HTLV-I) infection in Japan, 10 cases of liver cancer death occurred from 1984 through 1993.
To analyze the role of hepatitis C virus (HCV), which has been associated with an increasing incidence of hepatocellular carcinoma (HCC) in Japan, a nested case-control study was performed.
Five of the 10 liver cancer cases were positive for antibody to HTLV-I (anti-HTLV-1).
The possible interaction between HCV and HTLV-I infections in the etiology of HCC was investigated, with each liver cancer case matched to 5 cohort controls by gender, age, serum sample date and anti-HTLV-1 status.
Using a matched analysis, odds ratios (OR) were generated for the relationship between HCV serologic status and death from liver cancer.
Based on second-generation enzyme immunoassay with confirmation by recombinant immunoblot assay, 8 of 9 cases with adequate serum available (89%) and 9 of 50 (18%) controls were found to be positive for antibody to HCV (anti-HCV).
Liver cancer death was highly associated with anti-HCV (matched OR=p<0.001).
Anti-HTLV-I seroprevalence was somewhat correlated with HCV infection.
However, the high risk of liver cancer death observed for anti-HCV-positive individuals in this population did not vary with respect to whether or not the subjects were also infected with HTLV-1.
Mots-clés Pascal : Tumeur maligne, Foie, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Virus HTLV1, Retroviridae, Etiologie, Mortalité, Epidémiologie, Japon, Asie, Sud, Homme, Appareil digestif pathologie, Foie pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Liver, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, HTLV-I virus, Retroviridae, Etiology, Mortality, Epidemiology, Japan, Asia, South, Human, Digestive diseases, Hepatic disease, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0345548
Code Inist : 002B13C01. Création : 10/04/1997.