This prospective, clinical economic study was done to determine the cost impact of oral compared with intravenous (IV) ganciclovir for the maintenance treatment of newly diagnosed cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS).
Efficacy and safety data were extracted from a trial of oral and IV ganciclovir.
Medical care utilization and reimbursement data were obtained from the clinical trial, a survey of home care and nursing companies, an 11-member physician panel, and a Medicaid cost database.
The primary outcome measures were time to first retinitis progression and associated direct medical care expenditures.
Nonmedical costs and quality-of-life benefits were not considered.
Based on masked evaluation of retinal photographs, the Kaplan-Meier mean time to first progression was 62 days for IV ganciclovir and 57 days for oral ganciclovir (a nonsignificant difference).
The expected mean cost of treatment for IV ganciclovir was significantly different at $8587.00 compared with $4938.00 for oral treatment.
Sensitivity analysis using funduscopically determined mean time to first progression showed similar cost savings.
We concluded that oral ganciclovir is a cost-saving alternative to IV ganciclovir for the maintenance treatment of AIDS patients with newly diagnosed CMV retinitis. (...)
Mots-clés Pascal : Ganciclovir, Antiviral, Chimiothérapie, Rétinite, Cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, SIDA, Virose, Infection, Infection opportuniste, Voie orale, Etude comparative, Voie intraveineuse, Coût, Economie santé, Etats Unis, Amérique du Nord, Amérique, Traitement, Nucléoside acyclique, Purine nucléoside, Oeil pathologie, Rétinopathie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Antiviral, Chemotherapy, Retinitis, Cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, AIDS, Viral disease, Infection, Opportunistic infection, Oral administration, Comparative study, Intravenous administration, Costs, Health economy, United States, North America, America, Treatment, Acyclic nucleoside, Purine nucleoside, Eye disease, Retinopathy, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0340159
Code Inist : 002B02S05. Création : 10/04/1997.