Background and aims-Most colorectal cancers (CRC) arise in colorectal adenomas.
A case-control study was conducted to see whether a family history of CRC is associated with a higher prevalence of colorectal adenomas.
Subjects-Subjects were drawn from all patients who underwent colonoscopy at the Royal Brisbane Hospital between 1980-1982 and 1985, and included 141 cases with colorectal adenomas diagnosed at colonoscopy and 882 controls who were free of polyps at colonoscopy.
Methods-The prevalence of family history of CRC was compared between patients with adenomas and negative colonoscopy controls.
Overall, patients with one first degree relative with CRC were at no greater risk for adenomas at colonoscopy than patients with no family history (odds ratio (OR)=0.8,95% confidence intervals (CI)=0.4,1.5).
Patients with two or more affected first degree relatives had a more than doubled risk for adenomas (OR=2.3,95% CI=0.5,8.2), and were also more likely to carry moderately or severely dysplastic adenomas (OR=14.1,95% CI=2.0,62.9).
Conclusions-These findings are consistent with the hypothesis that some families, in addition to those with familial adenomatous polyposis, have an increased susceptibility to develop colorectal adenomas, and that adenomas in such families may have a greater tendency to undergo malignant transformation.
Mots-clés Pascal : Adénome, Côlon, Rectum, Déterminisme génétique, Facteur risque, Transformation maligne, Carcinome, Intérêt, Dépistage, Colonoscopie, Etude comparative, Homme, Tumeur bénigne, Côlon pathologie, Rectum pathologie, Appareil digestif pathologie, Maladie héréditaire, Tumeur maligne, Intestin pathologie, Endoscopie
Mots-clés Pascal anglais : Adenoma, Colon, Rectum, Genetic inheritance, Risk factor, Malignant transformation, Carcinoma, Interest, Medical screening, Colonoscopy, Comparative study, Human, Benign neoplasm, Colonic disease, Rectal disease, Digestive diseases, Genetic disease, Malignant tumor, Intestinal disease, Endoscopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0336628
Code Inist : 002B13B01. Création : 10/04/1997.