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  1. Nonsteroidal anti-inflammatory drug-induced hepatic disorders : Incidence and prevention.

    Article - En anglais

    The nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently used medications worldwide for the treatment of a variety of common chronic and acute inflammatory conditions.

    The association between NSAIDs and liver disease is poorly documented, the exceptions being sulindac and, to a lesser degree, diclofenac.

    The incidence of liver disease is very low and is relatively unimportant compared with the risk of peptic ulcer disease and gastrointestinal bleeding.

    Reports of hepatic injury range from insignificant and transient liver enzyme elevation to severe and fulminant hepatitis.

    Mots-clés Pascal : Sulindac, Diclofénac, Indométacine, Ibuprofène, Naproxène, Hépatite, Toxicité, Prévention, Incidence, Facteur risque, Antiinflammatoire non stéroïde, Homme, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Article synthèse, Indène dérivé, Indoleacétique acide dérivé, Appareil digestif pathologie, Foie pathologie, Arylacétique acide dérivé

    Mots-clés Pascal anglais : Hepatitis, Toxicity, Prevention, Incidence, Risk factor, Non steroidal antiinflammatory agent, Human, Epidemiology, United States, North America, America, Review, Indene derivatives, Indoleacetic acid derivatives, Digestive diseases, Hepatic disease, Arylacetic acid derivatives

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0335825

    Code Inist : 002B02U04. Création : 10/04/1997.