To examine the association between fat intake and the incidence of coronary heart disease in men of middle age and older.
Design-Cohort questionnaire study of men followed up for six years from 1986.
Setting-The health professionals follow up study in the United States.
Subjects-43 757 health professionals aged 40 to 75 years free of diagnosed cardiovascular disease or diabetes in 1986.
Main outcome measure-Incidence of acute myocardial infarction or coronary death.
During follow up 734 coronary events were documented, including 505 non-fatal myocardial infarctions and 229 deaths.
After age and several coronary risk factors were controlled for significant positive associations were observed between intake of saturated fat and risk of coronary disease.
For men in the top versus the lowest fifth of saturated fat intake (median=14.8% v 5.7% of energy) the multivariate relative risk for myocardial infarction was 1.22 (95% confidence interval 0.96 to 1.56) and for fatal coronary heart disease was 2.21 (1.38 to 3.54).
After ajustment for intake of fibre the risks were 0.96 (0.73 to 1.27) and 1.72 (1.01 to 2.90), respectively.
Positive associations between intake of cholesterol and risk of coronary heart disease were similarly attenuated after adjustment for fibre intake. (...)
Mots-clés Pascal : Cardiopathie coronaire, Régime alimentaire, Cholestérolémie, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Facteur risque, Adulte, Homme, Mâle, Etude longitudinale, Appareil circulatoire pathologie, Analyse biochimique
Mots-clés Pascal anglais : Coronary heart disease, Diet, Cholesterolemia, United States, North America, America, Epidemiology, Risk factor, Adult, Human, Male, Follow up study, Cardiovascular disease, Biochemical analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0334671
Code Inist : 002B12A03. Création : 10/04/1997.