Objectives-To determine if measures reflecting chronic occupational lead exposure are associated with performance on neuropsychological tests.
Method-467 Canadian male lead smelter workers (mean (SD) age 43.4 (11.00) years, education 9.8 (3.18) years, years of employment 17.7 (7.43), and current blood lead concentration (B-Pb) 27.5 (8.4) mug dl-1) were given a neuropsychological screening battery.
Time weighted average (TWA) and time integrated blood levels (IBL) were developed from B-Pb records obtained through regular medical monitoring (mean (range) TWA 40.1 (4.0-66.4) mug dl-1, mean IBL 765.2 (0.6-1625.7) mug-y dl-1). 14 neuropsychological variables were included in three multivariate analyses of covariance, with each exposure variable as the grouping variable (high, medium, and low) and age, education, score on a measure of depressive symptoms, and self reported alcohol use as the covariates.
Groups did not differ in history of neurological conditions.
Neither the B-Pb, TWA, nor IBL was significant by multivariate analyses of covariance (MANCOVA).
When years of employment, a suppressor variable, was included as a covariate, IBL exposure groups differed significantly on digit symbol, logical memory, Purdue dominant hand, and trails A and B. Conclusions-A dose-effect relation was found between cumulative exposure (IBL) and neuropsychological performance at a time when current B-Pb concentrations were low and showed no association with performance.
Mots-clés Pascal : Plomb, Métal lourd, Long terme, Toxicité, Test neuropsychologique, Fonderie, Exposition professionnelle, Homme, Système nerveux pathologie, Médecine travail, Dose cumulée, Epidémiologie, Canada, Amérique du Nord, Amérique, Psychométrie
Mots-clés Pascal anglais : Lead, Heavy metal, Long term, Toxicity, Neuropsychological test, Foundry, Occupational exposure, Human, Nervous system diseases, Occupational medicine, Cumulated dose, Epidemiology, Canada, North America, America, Psychometrics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0333069
Code Inist : 002B03L05. Création : 10/04/1997.