To assess the risk of cancer from inhalation of mineral acid mists.
Methods-A cohort study and nested case-control study of upper aerodigestive tumours were carried out in men employed since 1950 at two battery plants and two steel works in Britain.
The cohort was identified from personnel records and included 2678 men with definite exposure to acid mists (mainly sulphuric acid), 367 with possible exposure, and 1356 who were unexposed.
Mortality was compared with that in the national population by the person-years method.
Cases of upper aerodigestive cancer were identified from death certificates and cancer registrations, and their exposure to acids was compared with that of age matched controls (five per case) from the same plant by conditional logistic regression.
In follow up to 31 December 1993,93% of men were traced, including 1277 who had died.
Among the men definitely exposed to acid mists, overall mortality was less than in the national population (standardised mortality ratio (SMR) 0.92,95% confidence interval (95% CI) 0.85-0.98) as was mortality from all cancers (SMR 0.92,95% CI 0.79-1.05) and specifically from cancer of the larynx (SMR 0.48,95% CI 0.01-2.70) and lung (SMR 0.98,95% CI 0.78-1.22).
A total of 15 incident or fatal cases of upper aerodigestive cancer were identified during follow up. (...)
Mots-clés Pascal : Chlorhydrique acide, Sulfurique acide, Brume acide, Exposition professionnelle, Inhalation, Carcinogène, Homme, Tumeur maligne, Voie aérodigestive supérieure, Epidémiologie, Mortalité, Médecine travail, Toxicité, Angleterre, Grande Bretagne, Royaume Uni, Europe, Stomatologie, ORL pathologie, Appareil respiratoire pathologie, Appareil digestif pathologie, Industrie, Batterie, Fonderie acier
Mots-clés Pascal anglais : Hydrochloric acid, Sulfuric acid, Acid mist, Occupational exposure, Inhalation, Carcinogen, Human, Malignant tumor, Upper aerodigestive tract, Epidemiology, Mortality, Occupational medicine, Toxicity, England, Great Britain, United Kingdom, Europe, Stomatology, ENT disease, Respiratory disease, Digestive diseases, Industry, Battery, Steel foundry
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0333064
Code Inist : 002B03L02. Création : 10/04/1997.