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  1. Application of a single-compartment model for estimation of styrene uptake from measurements of urinary excretion of mandelic and phenylglyoxylic acids after occupational exposure.

    Article - En anglais

    In biological monitoring of styrene, the exposure is usually related to the urinary concentration of mandelic (MA) and/or phenylglyoxylic (PGA) acids in a urine sample taken after the workshift or on following morning.

    To study this relationship further, a single-compartment mathematical model was developed by which measured occupational repetitive uptake of styrene during a working day was related to measured excretion rates of the urinary metabolites.

    The model was used in practice to calculate the unknown uptake (dose) from MA and PGA excretion analyzed in urine samples.

    For comparison, a styrene limit dose was calculated from the exposure limit.

    Analytical results of samples from plastic boat builders were compared with the limit values.

    Mots-clés Pascal : Styrène, Exposition professionnelle, Homme, Toxicocinétique, Excrétion, Métabolite, Urine, Surveillance biologique, Modèle compartimental, Médecine travail

    Mots-clés Pascal anglais : Styrene, Occupational exposure, Human, Toxicokinetics, Excretion, Metabolite, Urine, Biological monitoring, Compartmental model, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0332574

    Code Inist : 002B03L06. Création : 10/04/1997.