Developmental neurotoxicity of PCBs in humans : What do we know and where do we go from here ? Commentaries. Author's reply.
The potential neurotoxicity of PCBs was first recognized in 1968 when a number of Japanese people became ill after ingesting rice oil that was contaminated with PCBs during the manufacturing process (Yusho).
Later a similar exposure occurred in Taiwan (YuCheng).
Children born to Taiwanese mothers who consumed PCB-contaminated rice oil were followed and a number of developmental abnormalities, including lower body weight and height, higher activity levels, greater incidence of behavior problems, and lower IQ scores, were observed.
However, interpretation of these findings is complicated by the fact that there did not appear to be any relationship between available indices of exposure and severity of effects, and by the fact that the PCBs to which the Taiwanese were exposed contained unusually high concentrations of dibenzofurans, which are many times more toxic than PCBs, and may have been responsible for some or all of the observed effects.
Since the Yusho and YuCheng episodes, several studies have been initiated to study the neurobehavioral effects of exposure to the lower levels of PCBs present in the environment.
The two studies published to date have yielded conflicting results.
Jacobson, Jacobson, and colleagues reported that in utero PCB exposure was associated with decreased birth weight and head circumference, shorter gestation, and several adverse outcomes on the Brazelton Neonatal Assessment Battery. (...)
Mots-clés Pascal : Biphényle(polychloro), Toxicité, Système nerveux pathologie, Homme, Gestation, Descendance, Tératogène, Trouble comportement, Lait femme, Intoxication alimentaire, Contamination, Aliment, Japon, Asie, Taiwan, Test neuropsychologique, Composé chimique, Epidémiologie, Malformation, Trouble mémoire, Yusho maladie, Yu cheng maladie
Mots-clés Pascal anglais : Polychlorobiphenyl, Toxicity, Nervous system diseases, Human, Pregnancy, Progeny, Teratogen, Behavioral disorder, Human milk, Food poisoning, Contamination, Food, Japan, Asia, Taiwan, Neuropsychological test, Chemical compound, Epidemiology, Malformation, Memory disorder
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0328640
Code Inist : 002A30E. Création : 10/04/1997.