Randomized controlled trial of a low animal protein, high fiber diet in the prevention of recurrent calcium oxalate kidney stones.
Low protein diets are commonly prescribed for patients with idiopathic calcium nephrolithiasis, who account for>80% of new diagnoses of kidney stones.
This dietary advice is supported by metabolic studies and epidemiologic observational studies but has not been evaluated in a controlled trial.
Using 1983-1985 data from three Northern California Kaiser Permanente Medical Centers, the authors randomly assigned 99 persons who had calcium oxalate stones for the first time to a low animal protein, high fiber diet that contained approximately 56-64 g daily of protein, 75 mg daily of purine (primarily from animal protein and legumes), one-fourth cup of wheat bran supplement, and fruits and vegetables.
Intervention subjects were also instructed to drink six to eight glasses of liquid daily and to maintain adequate calcium intake from dairy products or calcium supplements.
Control subjects were instructed only on fluid intake and adequate calcium intake.
Both groups were followed regularly for up to 4.5 years with food frequency questionnaires, serum and urine chemistry analysis, and abdominal radiography ; and they were urged to comply with dietary instructions.
In the intervention group of 50 subjects, stones recurred in 12 (7.1 per 100 person-years) compared with two (1.2 per 100 person-years) in the control group ; both groups received a mean of 3.4 person-years of follow-up (p=0.006). (...)
Mots-clés Pascal : Lithiase, Rein, Calcul calcique, Récidive, Epidémiologie, Régime alimentaire, Protéine animale, Fibre alimentaire, Prévention, Alimentation, Homme, Essai clinique, Californie, Etats Unis, Amérique du Nord, Amérique, Rein pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Lithiasis, Kidney, Calcium calculus, Relapse, Epidemiology, Diet, Animal protein, Dietary fiber, Prevention, Feeding, Human, Clinical trial, California, United States, North America, America, Renal disease, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0327751
Code Inist : 002B14E01. Création : 10/04/1997.