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  1. Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis a French case - control study.

    Article - En anglais

    A protective effect of calcium against colorectal cancer has been described in Anglo-Saxon but not in Latin communities, and no such effect has been observed regarding adenomas.

    We investigated the relationship between calcium, dairy products and the adenoma-carcinoma sequence in a French region by comparing small adenoma (<10 mm, n=154), large adenoma (n=208) and polyp-free (n=426) subjects, and cancer cases (n=171) with population controls (n=309).

    There was no protective effect of calcium against colorectal tumours except for low fat calcium and large adenomas in men (OR for highest quintile=0.3, P for trend=0.06).

    There was even a trend towards an increased risk of cancer with dairy calcium in men and non-dairy calcium in women.

    Vitamin D was inversely related to the risk of small adenomas in women (OR for highest quintile=0.4, P for trend=0.04).

    Regarding dairy products, only consumption of yoghurt displayed an inverse relationship with risk of large adenomas, in both men and women.

    These data failed to demonstrate a protective effect of calcium against colorectal carcinogenesis.

    They suggest that the type of dairy product might be the important factor with regard to prevention of colorectal tumours.

    Mots-clés Pascal : Carcinome, Adénome, Homme, Côlon, Rectum, Carcinogenèse, Protection, Epidémiologie, Calcium, Phosphore, Produit laitier, Vitamine D, Régime alimentaire, Elément minéral, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Etude cas témoin

    Mots-clés Pascal anglais : Carcinoma, Adenoma, Human, Colon, Rectum, Carcinogenesis, Protection, Epidemiology, Calcium, Phosphorus, Dairy product, Vitamin D, Diet, Inorganic element, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0324507

    Code Inist : 002B13B01. Création : 10/04/1997.