For this article we investigated the role of three blood antioxidant enzyme activities and total antioxidant status (TAS) as biological markers of oxidative stress in workers exposed to mercury (Hg°) vapors.
Twenty-two female workers took part in the study.
The examination included a questionnaire on age, educational level, occupational history, actual health status, previous accidents and diseases, smoking and dietary habits, and alcohol consumption.
Blood and urine sampling for biological analyses completed this examination.
The workers were classified into three subgroups according to their creatinine-corrected Hg concentration in urine.
Blood antioxidant enzyme activities and TAS were compared between groups with nonparametric distribution-free methods.
A significant difference existed in catalase activity and a slight, but not significant, difference existed in cu2+/Zn2+superoxide dismutase (Cu2+/Zn2+SOD) activity between the three groups.
No differences were observed in either the glutathione peroxidase activity or the TAS between these groups.
Catalase and Cu2+/Zn2+SOD activities were increased in the groups of workers with higher creatinine-corrected urinary Hg concentrations when compared with the group of lower creatinine-corrected urinary Hg concentrations. (...)
Mots-clés Pascal : Mercure, Métal lourd, Vapeur, Exposition professionnelle, Médecine travail, Homme, Toxicité, Activité enzymatique, Surveillance biologique, Marqueur biologique, Catalase, Peroxidases, Oxidoreductases, Enzyme, Superoxide dismutase, Stress oxydatif, Erythrocyte, Antioxydant
Mots-clés Pascal anglais : Mercury, Heavy metal, Vapor, Occupational exposure, Occupational medicine, Human, Toxicity, Enzymatic activity, Biological monitoring, Biological marker, Catalase, Peroxidases, Oxidoreductases, Enzyme, Superoxide dismutase, Oxidative stress, Red blood cell, Antioxidant
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0323935
Code Inist : 002B03L05. Création : 10/04/1997.