The multicentre south European study'Helios'II : different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas cell carcinomas of the skin.
The role of sun exposure in development of basal cell and squamous cell carcinomas among different populations from south Europe was investigated.
Between 1989 and 1993 we interviewed incident cases and a random population sample of controls from five centres where a cancer registry was operating, whereas we selected a sample of hospital-based cases and controls from the other three centres.
We gathered information on life-long exposure to sunlight during different activities.
Results are analysed for 1549 basal cell carcinoma (BCC) cases and 228 squamous cell carcinoma (SCC) cases compared with 1795 controls.
We observed a statistically significant increase of risk of SCC with increasing sun exposure beyond a threshold of 70 000 cumulated hours of exposure in a lifetime.
Sun exposures during work and holidays were, however, inversely correlated.
Odds ratios (ORs) of SCC were up to eight or nine times the reference for the highest exposures (200 000 cumulated hours or more).
BCC exhibited a 2-fold increase of risk for lower exposure (8000-10 000 cumulated hours in a lifetime) with a plateau and a slight decrease of risk for the highest exposures (100 000 cumulated hours or more).
Outdoor work showed a significantly increased risk of SCC (OR 1.6 for more than 54 000 cumulated hours of exposure in a lifetime), whereas recreational activities such as sun exposure during holidays at the beach (OR 1. (...)
Mots-clés Pascal : Carcinome basocellulaire, Carcinome épidermoïde, Peau, Facteur risque, Exposition, Rayonnement UV, Rayonnement solaire, Epidémiologie, Etiologie, Europe, Sud, Etude multicentrique, Peau pathologie, Tumeur maligne, Etude cas témoin
Mots-clés Pascal anglais : Basal cell carcinoma, Squamous cell carcinoma, Skin, Risk factor, Exposure, Ultraviolet radiation, Solar radiation, Epidemiology, Etiology, Europe, South, Multicenter study, Skin disease, Malignant tumor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0323682
Code Inist : 002B08A. Création : 10/04/1997.