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  1. A pharmacoeconomic model of divalproex vs. lithium in the acute and prophylactic treatment of bipolar I disorder.

    Article - En anglais


    Divalproex and lithium are the two most rigorously studied pharmacologic treatments for acute mania in bipolar I disorder in randomized, controlled trials.

    The differences between the drugs in their time course of onset, predictors of response, and side effects have potentially important pharmacoeconomic implications.


    Utilizing data from published studies, the University of Cincinnati Mania Project, and a consensus panel of psychiatrists, we developed a decision-analytic model to estimate the costs of treating patients with bipolar I disorder, acutely and prophylactically, for 1 year with divalproex or lithium.


    In the overall group of patients with bipolar I disorder, initial treatment with divalproex led to costs that were 9% lower than costs for initial treatment with lithium.

    Cost savings associated with divalproex were greatest for patients with mixed mania and rapid cycling, whereas cost savings for patients with classic mania were greater for lithium.


    According to the decision-analytic model developed in this study, divalproex, possibly because of a more rapid rate of antimanic activity associated with oral loading, is a less costly treatment than lithium in the acute and prophylactic treatment of patients with bipolar I disorder over 1 year.

    Mots-clés Pascal : Trouble bipolaire, Manie, Trouble humeur, Chimiothérapie, Traitement, Etude comparative, Valproate semisodique, Anticonvulsivant, Lithium, Psychotrope, Analyse coût, Economie santé, Homme

    Mots-clés Pascal anglais : Bipolar disorder, Mania, Mood disorder, Chemotherapy, Treatment, Comparative study, Anticonvulsant, Lithium, Psychotropic, Cost analysis, Health economy, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0323608

    Code Inist : 002B02B02. Création : 10/04/1997.