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  1. A pilot study on risk factors and p53 gene expression in colorectal cancer.

    Article - En anglais

    Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations.

    Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining.

    The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.

    Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Alcoolisme, Antihypertenseur, Hydralazine, Epidémiologie, Gène suppresseur tumeur, Expression génique, Suède, Europe, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Etude cas témoin, Gène p53

    Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Alcoholism, Antihypertensive agent, Epidemiology, Tumor suppressor gene, Gene expression, Sweden, Europe, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Case control study, p53 gene

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0321284

    Code Inist : 002B13B01. Création : 10/04/1997.