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  1. A non-random deletion in the p53 gene in oral squamous cell carcinoma.

    Article - En anglais

    In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included.

    Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47 ; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal.

    The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.

    Mots-clés Pascal : Carcinome épidermoïde, Cavité buccale, Délétion, Gène suppresseur tumeur, Tête cou, Mutation, Epidémiologie, Homme, Stomatologie, Cavité buccale pathologie, Tumeur maligne, Gène p53

    Mots-clés Pascal anglais : Squamous cell carcinoma, Oral cavity, Deletion, Tumor suppressor gene, Head and neck, Mutation, Epidemiology, Human, Stomatology, Oral cavity disease, Malignant tumor, p53 gene

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0321277

    Code Inist : 002B10B01. Création : 10/04/1997.