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  1. Infection by hepatitis C virus through contaminated intravenous immune globulin : results of a prospective national inquiry in France.

    Article - En anglais

    Background 

    A recent hepatitis C virus (HCV) outbreak has been suspected of being caused by an infusion of intravenous immune globulin.

    Study Design and Methods 

    Three laboratories were mandated by the French regulatory agency to prospectively screen on a national scale those persons having received suspected batches : 233 exposed patients were recalled and tested for HCV antibody and for HCV RNA.

    Results 

    Nineteen patients (8.1%) were found positive for HCV RNA ; 7 of these 19 were positive for the HCV antibody.

    Conclusion 

    The link between HCV infection and intravenous immune globulin was reinforced by the overrepresentation of the 2b genotype (58%), which contrasts with the low prevalence of this genotype in France (1%).

    Mots-clés Pascal : Hépatite virale C, Virose, Infection, Immunoglobuline, Voie intraveineuse, Origine humaine, Contamination, Epidémiologie, Traitement, Complication, Homme, France, Europe, Incidence, Appareil digestif pathologie, Foie pathologie, Transfusion, Constituant sang

    Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Immunoglobulins, Intravenous administration, Human origin, Contamination, Epidemiology, Treatment, Complication, Human, France, Europe, Incidence, Digestive diseases, Hepatic disease, Transfusion, Blood product

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0320406

    Code Inist : 002B27D01. Création : 10/04/1997.