A recent hepatitis C virus (HCV) outbreak has been suspected of being caused by an infusion of intravenous immune globulin.
Three laboratories were mandated by the French regulatory agency to prospectively screen on a national scale those persons having received suspected batches : 233 exposed patients were recalled and tested for HCV antibody and for HCV RNA.
Nineteen patients (8.1%) were found positive for HCV RNA ; 7 of these 19 were positive for the HCV antibody.
The link between HCV infection and intravenous immune globulin was reinforced by the overrepresentation of the 2b genotype (58%), which contrasts with the low prevalence of this genotype in France (1%).
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Immunoglobuline, Voie intraveineuse, Origine humaine, Contamination, Epidémiologie, Traitement, Complication, Homme, France, Europe, Incidence, Appareil digestif pathologie, Foie pathologie, Transfusion, Constituant sang
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Immunoglobulins, Intravenous administration, Human origin, Contamination, Epidemiology, Treatment, Complication, Human, France, Europe, Incidence, Digestive diseases, Hepatic disease, Transfusion, Blood product
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0320406
Code Inist : 002B27D01. Création : 10/04/1997.