- To assess susceptibility to poliomyelitis in selected inner-city preschool children in the United States and to estimate the contribution of secondary spread of live attenuated oral poliovirus vaccine virus to type-specific immunity.
- Cross-sectional seroprevalence study.
- Serum neutralizing antibody levels against poliovirus types 1,2, and 3 were analyzed according to vaccination status, age, and other sociodemographic variables.
- Hospital and satellite clinics serving inner-city populations in Houston, Tex, and Detroit, Mich, 1990 to 1991.
- A total of 526 children aged 12 to 47 months seeking medical care were enrolled in the seroprevalence study ; 144 children aged 12 to 35 months without a history of previous oral poliovirus vaccination were enrolled in the secondary spread study.
- Seropositive rates were similar in children in both cities, ranging from about 80% for types 1 and 3 in 12-to 23-month-old children to more than 90% in those aged 36 to 47 months.
The most important predictor of seropositivity was the number of doses of oral poliovirus vaccine received (P<. 01), with levels approximately 90% for all 3 serotypes among children who had received 3 or more doses. (...)
Mots-clés Pascal : Etats Unis, Amérique du Nord, Amérique, Poliomyélite antérieure, Virose, Infection, Séropositivité, Prévalence, Enfant, Homme, Age préscolaire, Milieu urbain, Politique sanitaire, Vaccination, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie
Mots-clés Pascal anglais : United States, North America, America, Acute anterior poliomyelitis, Viral disease, Infection, Seropositivity, Prevalence, Child, Human, Preschool age, Urban environment, Health policy, Vaccination, Nervous system diseases, Central nervous system disease, Spinal cord disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0319641
Code Inist : 002B05C02A. Création : 10/04/1997.