Breast cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with breast cancer mortality in the atomic bomb survivors study.
The relationship between exposure to low-linear energy transfer ionizing radiation and subsequent breast cancer mortality risk is reported based on a further 7 years of follow-up in the Canadian fluoroscopy study.
Amongst 31,917 women first treated for tuberculosis in a Canadian institution between 1930 and 1952, a total of 688 breast cancer deaths were observed between 1950 and 1987.
There is a strong linear trend of increasing risk with increasing dose (P<0.0001), with the excess relative risk per sievert decreasing with age at exposure (P=0.0003).
The excess relative risk is approximately constant between 5 and 39 years after exposure, with a suggestion of a decrease between 40 and 57 years after exposure, though this could be a chance effect (P=0.22).
Combined analyses of the Canadian fluoroscopy data and the data for the atomic bomb survivors with respect to breast cancer mortality are also reported.
In general the two studies are reasonably consistent, the only distinct difference being the much greater excess relative risk per sievert amongst women exposed to very high doses in the province of Nova Scotia (P, heterogeneity<0.0001).
Based on the combined data sets a simple relative risk (RR) model for the effect of a dose of D sieverts at age A years is developed : RR (D)=1.0+0.52D exp[-0.10 (A - 15) ]. (...)
Mots-clés Pascal : Etude comparative, Radiocontamination, Effet biologique, Tumeur maligne, Glande mammaire, Mortalité, Rayonnement ionisant, Dose fractionnée, Explosion nucléaire, Survivant, Homme, Femelle, Canada, Amérique du Nord, Amérique, Population, Glande mammaire pathologie
Mots-clés Pascal anglais : Comparative study, Radioactive contamination, Biological effect, Malignant tumor, Mammary gland, Mortality, Ionizing radiation, Fractionated dose, Nuclear explosion, Survivor, Human, Female, Canada, North America, America, Population, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0318967
Code Inist : 002A08F03. Création : 10/04/1997.