To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey.
Sixty-nine subjects were diagnosed with breast cancer subsequent to urine collection.
Among women who were premenopausal at the time of urine collection, cases excreted less oestrogen than controls ; the odds ratios (95% CI) for breast cancer in the middle and upper thirds of the distribution of oestrogen excretion, in comparison with the lower third (reference group, assigned odds ratio=1.0), were 0.5 (0.2-1.2) and 0.4 (0.2-1.1) respectively for oestrone, 0.8 (0.4-1.8) and 0.4 (0.2-1.1) for oestradiol, 0.7 (0.3-1.6) and 0.7 (0.3-1.6) for oestriol and 0.9 (0.4-2.0) and 0.5 (0.2-1.3) for total oestrogens.
Among women who were post-menopausal at the time of urine collection, the trend was in the opposite direction, with an increase in risk associated with increased oestrogen excretion ; the odds ratios were 0.9 (0.3-2.2) and 1.1 (0.5-2.8) for oestrone, 0.8 (0.3-2.3) and 1.9 (0.8-4.6) for oestradiol, 1.5 (0.6 3.9) and 1.8 (0.7-4.6) for oestriol and 0.9 (0.4-2.6) and 1.9 (0.7-4.7) for total oestrogens.
The trends of increasing risk with increasing oestrogen excretion among post-menopausal women were statistically significant for oestradiol (P=0.022) and for total oestrogens (P=0. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Oestrogène, Urine, Prospective, Homme, Glande mammaire pathologie, Ile Guernesey
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Estrogen, Urine, Prospective, Human, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0318097
Code Inist : 002B20E02. Création : 10/04/1997.