Spatial clustering of childhood cancers in Great Britain.
Firstly, to identity spatially close pairs and triplets of childhood leukaemias and cancers in Britain.
Secondly, to compare pair frequencies with random expectations, identify excesses, and measure the diameters of any clusters.
Thirdly, to infer possible causes.
Design and setting
Stratified Poisson analyses of two comprehensive sets of childhood leukaemia and cancer data in Great Britain : seeking home address pairs within particular census enumeration districts (EDs) or postcodes (PCs).
Numbers of pairs/triplets of leukaemia registrations sharing single or adjacent EDs were compared with Poisson expectations in national ED strata with different numbers of households (HHs).
Pairsltriplets of leukaemia/cancer deaths (and births) sharing a single PC were compared with Poisson expectations in national PC strata with different numbers of postal delivery points (DPs).
Same and adjacent house pairs were identified individually among the same PC death pairs.
Areal case densities were estimated around a sample of index cases, using their own PC grid coordinates, and those recorded in the central PC directory.
These comprised, firstly, all cases of childhood leukaemia and non-Hodgkin lymphoma registered between 1966 and 1983 in England and Wales (ED analysis) and, secondly, all childhood leukaemia and cancer deaths between 1953 and 1980, in England, Wales, and Scotland (PC analyses at birth and at death). (...)
Mots-clés Pascal : Tumeur maligne, Leucémie, Epidémiologie, Analyse amas, Analyse spatiale, Enfant, Homme, Variation géographique, Analyse statistique, Royaume Uni, Europe, Hémopathie maligne
Mots-clés Pascal anglais : Malignant tumor, Leukemia, Epidemiology, Cluster analysis, Spatial analysis, Child, Human, Geographical variation, Statistical analysis, United Kingdom, Europe, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0317969
Code Inist : 002B04B. Création : 10/04/1997.