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  1. Verbal autopsy as a tool for diagnosing HIV-related adult deaths in rural Uganda.

    Article - En anglais

    Background

    In general, information on the causes of adult deaths in developing countries is scarce.

    More specifically, relatively little is known about the effect of HIV-1 associated disease on adult mortality in general populations.

    In this study we have used a verbal autopsy technique to ascertain whether adult deaths were associated with HIV-1 in a rural population with a prevalence of HIV-1 infection of 8%, and used HIV-1 antibody status to validate the verbal autopsy findings.

    Methods

    All adult deaths in the population cohort that occurred between December 1990 and November 1993 were identified through a monthly death registration system.

    Approximately 2 months after death, a relative of the deceased was interviewed by a trained nurse, and questionnaires were assessed by at least two independent clinicians ; all were unaware of the HIV serostatus of the deceased.

    Results

    A total of 155 adult deaths was assessed, i.e. 53% of all recorded adult deaths.

    Of those assessed half were HIV-1 positive.

    In all 47% of deaths were classified as HIV-related.

    The overall specificity and positive predictive value of the verbal autopsy tool were both 92% ; in those aged 13-44 years (83 adults) the corresponding values were 85% and 95% respectively.

    The verbal autopsy estimated HIV-1 attributable mortality fraction was similar to the calculated fraction based on prospective data.

    Conclusions

    (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Mortalité, Epidémiologie, Diagnostic, Autopsie, Communication verbale, Milieu rural, Ouganda, Afrique, Homme, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Complication, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Mortality, Epidemiology, Diagnosis, Autopsy, Verbal communication, Rural environment, Uganda, Africa, Human, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Complication, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0317946

    Code Inist : 002B06D01. Création : 10/04/1997.