Verbal autopsy as a tool for diagnosing HIV-related adult deaths in rural Uganda.
In general, information on the causes of adult deaths in developing countries is scarce.
More specifically, relatively little is known about the effect of HIV-1 associated disease on adult mortality in general populations.
In this study we have used a verbal autopsy technique to ascertain whether adult deaths were associated with HIV-1 in a rural population with a prevalence of HIV-1 infection of 8%, and used HIV-1 antibody status to validate the verbal autopsy findings.
All adult deaths in the population cohort that occurred between December 1990 and November 1993 were identified through a monthly death registration system.
Approximately 2 months after death, a relative of the deceased was interviewed by a trained nurse, and questionnaires were assessed by at least two independent clinicians ; all were unaware of the HIV serostatus of the deceased.
A total of 155 adult deaths was assessed, i.e. 53% of all recorded adult deaths.
Of those assessed half were HIV-1 positive.
In all 47% of deaths were classified as HIV-related.
The overall specificity and positive predictive value of the verbal autopsy tool were both 92% ; in those aged 13-44 years (83 adults) the corresponding values were 85% and 95% respectively.
The verbal autopsy estimated HIV-1 attributable mortality fraction was similar to the calculated fraction based on prospective data.
Mots-clés Pascal : SIDA, Virose, Infection, Mortalité, Epidémiologie, Diagnostic, Autopsie, Communication verbale, Milieu rural, Ouganda, Afrique, Homme, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Complication, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Mortality, Epidemiology, Diagnosis, Autopsy, Verbal communication, Rural environment, Uganda, Africa, Human, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Complication, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0317946
Code Inist : 002B06D01. Création : 10/04/1997.