Chlamydia pneumoniae antibodies in chronic obstructive pulmonary disease.
The significance of persistent or recurrent respiratory infections in adult life for the development of chronic obstructive pulmonary disease (COPD) is still to a large extent unknown.
A few clinical and experimental animal studies suggest that peripheral airways diseases may be due to the cumulative effects of recurrent respiratory infections over an extended period.
C. pneumoniae-specific IgG and IgA antibody levels were determined in two elderly groups of male patients with COPD and in control subjects without the disease.
The first group (N=36) consisted of patients who were hospitalized due to an acute exacerbation of COPD.
The second group of patients (N=54) and the controls (N=321) were participants in a community survey on respiratory diseases in the elderly.
The criteria for seropositivity were defined as an IgG titre of =32 and an IgA titre of =16.
89% of the hospitalized patients (group 1) and 66% of the non-hospitalized patients (group II) were IgA-seropositive as compared to 55% of the controls.
Derived from the logistic regression analysis, the odds ratio (OR) was 7.4 (95% Cl : 2.1-25.7) between group I and the controls and 1.5 (0.7-2.9) between group II and the controls.
Furthermore, the difference in the age-adjusted geometric mean titres (GMT) of IgA antibodies between the group I and the controls was significant (53.0 for the patients versus 19.1 for the controls). (...)
Mots-clés Pascal : Bronchopneumopathie obstructive, Chronique, Epidémiologie, Sérologie, Etiologie, Bactériose, Infection, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bactérie, Vieillard, Homme, Finlande, Europe, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Obstructive pulmonary disease, Chronic, Epidemiology, Serology, Etiology, Bacteriosis, Infection, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bacteria, Elderly, Human, Finland, Europe, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0317941
Code Inist : 002B11B. Création : 10/04/1997.