The significance of persistent or recurrent respiratory infections in adult life for the development of chronic obstructive pulmonary disease (COPD) is still to a large extent unknown.
A few clinical and experimental animal studies suggest that peripheral airways diseases may be due to the cumulative effects of recurrent respiratory infections over an extended period.
C. pneumoniae-specific IgG and IgA antibody levels were determined in two elderly groups of male patients with COPD and in control subjects without the disease.
The first group (N=36) consisted of patients who were hospitalized due to an acute exacerbation of COPD.
The second group of patients (N=54) and the controls (N=321) were participants in a community survey on respiratory diseases in the elderly.
The criteria for seropositivity were defined as an IgG titre of =32 and an IgA titre of =16.
89% of the hospitalized patients (group 1) and 66% of the non-hospitalized patients (group II) were IgA-seropositive as compared to 55% of the controls.
Derived from the logistic regression analysis, the odds ratio (OR) was 7.4 (95% Cl : 2.1-25.7) between group I and the controls and 1.5 (0.7-2.9) between group II and the controls.
Furthermore, the difference in the age-adjusted geometric mean titres (GMT) of IgA antibodies between the group I and the controls was significant (53.0 for the patients versus 19.1 for the controls). (...)
Mots-clés Pascal : Bronchopneumopathie obstructive, Chronique, Epidémiologie, Sérologie, Etiologie, Bactériose, Infection, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bactérie, Vieillard, Homme, Finlande, Europe, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Obstructive pulmonary disease, Chronic, Epidemiology, Serology, Etiology, Bacteriosis, Infection, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bacteria, Elderly, Human, Finland, Europe, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0317941
Code Inist : 002B11B. Création : 10/04/1997.