2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism in animals ; however, evidence for such an effect in humans is conflicting.
This conflict was addressed using data from a cross-sectional medical study conducted between 1987 and 1988.
The exposed participants had been employed at least 15 y earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two chemical plants in the United States.
A total of 281 workers and 260 unexposed referents participated.
Workers had substantial exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, evidenced by a median serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration of 406.6 femtograms/gram of serum (fg/g serum), compared with 36.9 fg/g serum among the referents.
A slight association between triglyceride concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration was found (p=05).
Over the range of observed 2,3,7,8-tetrachlorodibenzo-p-dioxin values (i.e., 37-19 000 fg/g serum), triglyceride concentration increased only about 0.4 mmol/l. No association was found between an abnormally elevated triglyceride (i.e.,>2.82 mmol/l) concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration.
An association was also found between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration and an abnormal high-density lipoprotein concentration (p=09). (...)
Mots-clés Pascal : Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Toxicité, Exposition professionnelle, Médecine travail, Homme, Lipide, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Toxicity, Occupational exposure, Occupational medicine, Human, Lipids, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0315638
Code Inist : 002B03L06. Création : 10/04/1997.