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  1. Trends in pharmacotherapy of schizoaffective and bipolar affective disorders : A 5-year naturalistic study.

    Article - En anglais


    The authors'goal was to determine if the actual treatment of schizoaffective and bipolar affective disorders has changed in light of recent clinical drugs trials that have suggested that valproate and carbamazepine may be equivalent in efficacy to lithium.


    Medication utilization rates for each 6-month period from July 1,1989, to June 30,1994, were compiled from the clinical database of the Palo Alto Veterans Affairs Medical Center.


    The use of valproate and valproate plus lithium was negligible in 1989.

    By 1994, these medication regimens accounted for 25% of the standard antimanic treatments used for bipolar affective disorder and 38% of the treatments used for schizoaffective disorder.

    Regimens of carbamazepine and carbamazepine plus lithium dropped from 24% of antimanic treatments in 1989 to 18% in 1994.

    From 1989 to 1994, there was a decline in the rate of lithium monotherapy for treatment of bipolar affective disorder (from 84% to 43%) and schizoaffective disorder (from 100% to 53%). Conclusions : In the past 5 years, valproate monotherapy has increased as a percentage of total antimanic pharmacotherapies, while lithium monotherapy has declined.

    Mots-clés Pascal : Psychose schizoaffective, Psychose, Trouble bipolaire, Trouble humeur, Etude longitudinale, Chimiothérapie, Traitement, Evolution, Psychotrope, Lithium, Valproïque acide, Carbamazépine, Homme, Normothymique

    Mots-clés Pascal anglais : Schizoaffective psychosis, Psychosis, Bipolar disorder, Mood disorder, Follow up study, Chemotherapy, Treatment, Evolution, Psychotropic, Lithium, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0315335

    Code Inist : 002B02B02. Création : 10/04/1997.