logo BDSP

Base documentaire


  1. Understanding the relationship between relative and absolute risk.

    Article - En anglais

    BACKGROUND

    Relative risks are the most common statistics used to quantify the risk of mortal or morbid outcomes associated with different patient groups and therapeutic interventions.

    However, absolute risks are of greater value to both patient and physician in making clinical decisions.

    METHODS

    The relationship between relative and absolute risks is explained using graphical aids.

    A program to estimate absolute risks from relative risks is available on the Internet (see ftp :/ftp. vanderbilt. edu/pub/biostat/absrisk. txt).

    This program uses a competing hazards model of morbidity and mortality to derive these estimates.

    RESULTS

    When a patient's absolute risk is low, it can be approximated by multiplying her relative risk by the absolute risk in the reference population.

    This approximation fails for higher absolute risks.

    The relationship between relative and absolute risk can vary dramatically for different diseases.

    This is illustrated by breast cancer morbidity and cardiovascular mortality in American women.

    The accuracy of absolute risk estimates will be affected by the accuracy of relative risk estimates, by the appropriateness of the reference groups used to calculate relative risks, by the stability of cross-sectional, age-specific morbidity and mortality rates over time, by the influence of individual risk factors on multiple causes of mortality, and by the extent to which relative risks may vary over time.

    CONCLUSIONS

    (...)

    Mots-clés Pascal : Carcinome, Glande mammaire, Facteur risque, Epidémiologie, Modèle mathématique, Homme, Tumeur maligne, Glande mammaire pathologie, Risque absolu, Risque relatif

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Risk factor, Epidemiology, Mathematical model, Human, Malignant tumor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0308250

    Code Inist : 002B30A01A1. Création : 10/04/1997.