We applied the recently reported consensus criteria for frontotemporal dementia (FTD) to 12 patients presenting with a frontal-type dementia.
All 12 patients fulfilled the Manchester/Lund consensus criteria and had at least five of the behavioural abnormalities listed as core diagnostic clinical features.
Speech abnormalities were, by contrast, an inconsistent and late feature.
We also reviewed the psychiatric symptomatology in the same group of patients ; although six (50%) were diagnosed as FTD at presentation, 33% received an initial psychiatric diagnosis.
These were schizophreniform psychosis, depression with obsessive-compulsive features, alcohol dependency, and psychogenic memory impairment.
Major depression (DSM-IV) appears to be unusual, but depressive symptoms are common.
The Mini-Mental State Examination (MMSE) was found to be an insensitive measure ; it was within the normal range (>23) in 72% of patients.
However, verbal fluency (production of words beginning with F, A, and S) was markedly reduced in all but one case.
The prognosis appears to be poor ; most patients declined rapidly and required part-or full-time support within 24 months of diagnosis.
Mots-clés Pascal : Association morbide, Trouble psychiatrique, Démence, Lobe frontal, Lobe pariétal, Fluidité verbale, Prévalence, Epidémiologie, Homme, Démence Pick, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Concomitant disease, Mental disorder, Dementia, Frontal lobe, Parietal lobe, Verbal fluidity, Prevalence, Epidemiology, Human, Pick disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0307414
Code Inist : 002B18C13. Création : 10/04/1997.