Regional metastases in patients with advanced laryngeal cancer.
Annual Meeting of the American Society for Head and Neck Surgery. Palm Desert, Calif, USA, 1995/04/29.
To determine patterns of regional metastases in patients with advanced squamous cell carcinoma of the larynx and the effect of these patterns on regional and distant tumor recurrence and disease-free and overall survival.
One hundred fifty-nine patients treated with conventional surgery and radiation in the Veterans Affairs Cooperative Study were studied.
Ninety-three of the patients underwent modified or classic radical neck dissection.
Median follow-up was 5 years.
Patient data collected included age, gender, alcohol consumption, tobacco use, and performance status.
Tumor variables evaluated included TNM classification, tumor site, surface area, presence of ulceration and invasion, and histologic growth pattern.
Histologically positive regional lymph nodes were examined for level, number, site, and extracapsular spread.
Outcome variables included time and location of recurrence, distant metastases, and survival.
Regional metastases were more common in supraglottic than glottic or subglottic tumors (P<. 001) and in tumors with larger surface dimensions (P=004).
Cervical metastases were associated with decreased disease-free interval (P<. 001) and survival (P=001) and increased distant metastases (P<. 001).
Presence of3 or more positive nodes predicted distant recurrence (P<. 001) and decreased survival (P<. 001, multivariate analysis). (...)
Mots-clés Pascal : Carcinome épidermoïde, Larynx, Homme, Métastase, Complication, Stade avancé, Adénopathie, Ganglion lymphatique, Pronostic, Survie, Epidémiologie, Tête cou, Voie respiratoire supérieure, Tumeur maligne, Larynx pathologie, ORL pathologie
Mots-clés Pascal anglais : Squamous cell carcinoma, Larynx, Human, Metastasis, Complication, Advanced stage, Adenopathy, Lymph node, Prognosis, Survival, Epidemiology, Head and neck, Upper respiratory tract, Malignant tumor, Larynx disease, ENT disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0306072
Code Inist : 002B10B01. Création : 10/04/1997.